منابع مشابه
Renal function in a rat model of analgesic nephropathy: effect of chloroquine.
The antimalaria drug chloroquine is often taken against a background of analgesic nephropathy caused by nonsteroidal anti-inflammatory drugs such as paracetamol (acetaminophen). Chloroquine has marked effects on the normal kidney and stimulates an increase in plasma vasopressin via nitric oxide. The aim of this study was to determine the renal action of chloroquine in a model of analgesic nephr...
متن کاملAnalgesic nephropathy.
Many questions about analgesic nephropathy (AN) lack clear-cut answers. We present available evidence for and against proposed answers to many of these questions. These include: (1) Is acetaminophen (AC) nephrotoxic when taken as the sole analgesic? (2) Is the combination of acetylsalicylic acid (ASA) and AC more nephrotoxic than AC taken alone, and if so, why? (3) What are the minimum doses an...
متن کاملAnalgesic use and renal function in men.
CONTEXT Several case-control studies suggest an association between analgesic use and increased risk of chronic renal disease, but few cohort studies have examined this association. OBJECTIVE To determine whether analgesic use is associated with risk of renal dysfunction. DESIGN AND SETTING Cohort study of analgesic use data from the Physicians' Health Study, which lasted 14 years from Sept...
متن کاملAnalgesic nephropathy: renal distribution of acetaminophen and its conjugates.
Acetaminophen (APAP) and its conjugates (APAP-conj) are the major metabolites of phenacetin. To study their significance in the pathogenesis of analgesic nephropathy, their concentrations in the renal parenchyma were determined in conjunction with clearance measurements in 15 dogs with inulin as a reference marker. Particular attention was given to interpretation of the mechanisms responsible f...
متن کاملAspirin and analgesic nephropathy.
Renal function was studied in 17 patients with rheumatoid arthritis who had each consumed between 5 and 20 kg of aspirin. After an interval of two years 14 of these patients-seven of whom had consumed a further mean of 2 kg of aspirin-had their renal function retested. No relation was found between total dose, rate, or duration of ingestion and any aspect of renal function that was studied. All...
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ژورنال
عنوان ژورنال: BMJ
سال: 1969
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5651.213